Method for planning in vivo formulation：Get μL DMSO learn liquid, subsequent increase μL Corn oil，combine and explain.
The dilution calculator is a useful gizmo which lets you calculate how you can dilute a stock solution of known focus. Enter C1, C2 & V2 to estimate V1.
forty three uM in SPR assays, binding to OC2-HOX domain right. CSRM617 induces apoptosis by look of cleaved Caspase-3 and PARP. CSRM617 is very well tolerated within the prostate cancer mouse product
CSRM617 hydrochloride (CSRM-617) is a little-molecule inhibitor on the transcription aspect ONECUT2 (OC2) with Kd of 7.forty three uM in SPR assays, binds to OC2-HOX area immediately; inhibits mobile development and induced apoptosis in vitro in several Laptop cell traces that expressed average to significant levels of OC2; noticeably downregulates PEG10 protein stages in tumors from mice treated with CSRM617, suppresseses metastasis in 22Rv1 cells implanted subcutaneously nude mice.
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